Effectiveness of equivalent schedules of full-dose inactivated poliovirus vaccine injected into muscle compared to a smaller dose injected into skin

This Cochrane Review, published December 2019, compares the immunogenicity and efficacy of an inactivated poliovirus vaccine (IPV) in equivalent immunisation schedules using fractional-dose IPV injected into skin to full-dose IPV injected into muscle.

It includes 13 randomised controlled trials with 7292 participants. The results were as follows. 

  • No study reported on paralytic poliomyelitis.
  • Seroconversion rates were higher in the intramuscular group for all three types of poliovirus after one and two doses, and for type two poliovirus only, after three doses (low and very low-certainty evidence).
  • Median antibody titres were higher in the intramuscular group for all three types of poliovirus (very low-certainty evidence). 
  • Five studies (2217 children) reported more adverse events (e.g. fever and redness) in the intradermal group, whilst two studies (1904 children) reported more adverse events in the intramuscular group (very low-certainty evidence). 

Read the full review on the Cochrane Library